I bought a program called KU TOOLs that at a keystroke could remove (but not replace) drop capitals from the printed version of Air Crashes and Miracle Landings before putting it on the Kindle. as they did not work there. There was an expensive program that could do it, but judging from a professionally produced book I read on the Kindle the result was hardly pleasing.
When I recently made a Kindle file submission test run on getting my book ready for pre-orders I left the drop capitals in and they came out really beautiful. (BTW, I had set them to drop two lines on the printed version, and the Kindle dropped them three which in view of the smaller size was perfect.)
This is wonderful as I can have the basic book the same for both printed and Kindle versions and not have to update two and risk getting them out of sync.
Note: The interior file I submitted to Amazon Kindle was a “Web Page (filtered) htm, html using Word (Office 365)
Christopher Bartlett (Author/Publisher)